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hives (itchy bumps) swelling of your tongue, mouth, or throat.Call your provider right away if you have: mental changes such as seeing things that are not there (hallucinations), agitation, or coma fast heartbeat changes in blood pressure high body temperature tight muscles or trouble walking. serotonin syndrome, a rare but serious problem that can happen in people using Tosymra, especially when used with anti-depressant medicines called SSRIs or SNRIs.If your headaches get worse, call your provider. medication overuse headaches from using migraine medicine for 10 or more days each month.increased blood pressure including a sudden severe increase even if you have no history of high blood pressure.cramping and pain in your legs or hips, feeling of heaviness or tightness in your leg muscles, burning or aching pain in your feet or toes while resting, numbness, tingling, or weakness in your legs, cold feeling or color changes in one or both legs or feet.sudden or severe stomach pain, stomach pain after meals, weight loss, nausea or vomiting, constipation or diarrhea, bloody diarrhea, fever.changes in color or sensation in your fingers and toes.Tosymra may cause serious side effects including: If so, do not drive a car, use machinery, or do anything where you need to be alert. Tosymra can cause dizziness, weakness, or drowsiness. Tell your provider about all of your medical conditions and medicines you take, including vitamins and supplements. an allergy to sumatriptan or any ingredient in Tosymra.Ask your provider for a list of these medicines if you are not sure. are taking certain antidepressants, known as monoamine oxidase (MAO)-A inhibitors or it has been 2 weeks or less since you stopped taking a MAO-A inhibitor.Ask your provider if you are not sure if your medicine is listed above. taken any of the following medicines in the last 24 hours: almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, ergotamines, or dihydroergotamine.had a stroke, transient ischemic attacks (TIAs), or problems with blood circulation.If you are not sure if you have these, ask your healthcare provider.
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Tosymra is not for people with risk factors for heart disease (high blood pressure or cholesterol, smoking, overweight, diabetes, family history of heart disease) unless a heart exam is done and shows no problem. shortness of breath with or without chest discomfort.pain or discomfort in your arms, back, neck, jaw, or stomach.severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw.discomfort in the center of your chest that lasts for more than a few minutes or goes away and comes back.Stop Tosymra and get emergency medical help if you have any signs of heart attack: Tosymra ® can cause serious side effects, including heart attack and other heart problems, which may lead to death.